The snake has harmful, auspicious, and respectable spiritual and cultural implications. It is the devil embodied, an old totem, a king's guardian, a symbol of knowledge and power, and an omen of good fortune and health. Overall, the snake has a deep cultural and enigmatic meaning.

In China, the snake is a sign of good luck and dignity.

The snake was supposed to have the ability to extend life in ancient China, and it was regarded as a sign of good fortune, abundant crop, and reproduction. In southwestern and southern China, snake-themed cultural artifacts were common. On a bronze jug discovered in Gongcheng, Guangxi province, there are vibrant designs of two snakes fighting with frogs dating back to the Spring and Autumn Period.

The snake was regarded as a sign of bountiful harvest and the soil by ancient peoples in southern China. The snake is frequently depicted on bronze cultural relics used for worshiping and praying for a plentiful crop.

The snake has a tight relationship with gods in Chinese mythology. In Han Dynasty stone and brick murals, Fu Xi and Nv Wa are shown as snakes with snake bodies and tails, their hands clutching the sun and moon, since some people believed them to be sun god and moon goddess. There are also depictions of them with dragon bodies and tails holding the gauge and square. Fu Xi and Nv Wa are encircled by stars in a silk artwork uncovered from the Astana Graves in Turpan, Xinjiang, and clasp each other firmly with their snake bodies and tails interlaced, representing the grave owners' longing for more progeny.

The Legend of the White Snake is a well-known ancient Chinese tale of devoted love that has been adapted into operas, films, dances, New Year paintings, and shadow plays.

In Egypt and India, the snake is a sign of divinity and eternity.

Unlike the Bible, ancient Egyptian and Indian mythology viewed the serpent as a divine emblem rather than the incarnation of the devil.

After the Nile river retreated, the snake was the first animal to emerge. It was said to be an underworld entity with the ability to create the universe. The universe was formed by four goddesses with snake heads and four gods with frog heads, according to Egyptian mythology. They formed four pairs, symbolizing the primordial sea's ability to reproduce. Amun, the Egyptian sun deity, is frequently shown as a snake constantly consuming its own tail, which represents eternity and endless cycles of regeneration.

"Naga" is the name given to a collection of snake gods in Indian mythology. Naga were frequently depicted by ancient Indian Buddhists and Hindus as having human heads and snake tails, as well as five or seven cobra heads arranged in a marquee. The relief of serpent gods and goddesses swimming in the Ganges on the Descent of the Ganges at Mahabalipuram in southern India, which dates back to 670, is a good example. The snake is also a symbol of eternity in Indian mythology, especially when it bites its own tail.